Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia.

In the OT2 Rag Tx, OT2 Tx, and WT Tx mice, we found a similar highly significant correlation of the percentage of PD1+ CD4+ T cells with the amount of endogenous Vb5neg T cells (Vb5neg fraction: OT2 Rag mean 56.6%, SD 16.8%, n = 4; OT2 mean 35%, SD 17.3%, n = 12; WT mean 91.5%, SD 1.8%, n = 12) ( Figure 3 G).

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