Co-evolutionary landscape at the interface and non-interface regions of protein-protein interaction complexes.

Comput Struct Biotechnol J · 2021 · PMC8271121 · PMID 34285778

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probable significanceno p-value reported

In order to study the probable significance of co-evolutionary pairings which are not occurring in close spatial proximity, we have studied co-evolution patterns in certain receptor-ligand protein hetero-dimers that are known to interact aberrantly during cancer metastasis.

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