Characterization of anti-nuclear antibodies in patients with oral submucous fibrosis and its clinicopathologic implications - An immunofluorescence study.

This is also supported by the fact that the autoantibodies appear long before the disease becomes clinically evident.[ 18 ] In the present study, ANA positive and negative cases in the patient group did not show any significant difference in duration and frequency of the habit.[ Table 2 ] Chiang et al .[ 14 ] documented no association with duration of habit and a borderline significant association with frequency of habit ( P = 0.066).

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