Cisplatin Ototoxicity: Examination of the Impact of Dosing, Infusion Times, and Schedules In Pediatric Cancer Patients.

Front Oncol · 2021 · PMC8274419 · PMID 34262862

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trending toward significanceno p-value reported

Like hearing loss, worsening SIOP grade was associated with age (p <0.0001), radiation to any part of the body (p=0.023), and amount of CDDP per dose (p=0.037) on multivariate analysis, with cumulative dosing trending toward significance (0.057) ( Table 3 ).

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failed to reach significanceno p-value reported

Other parameters such as number of doses, number of doses per cycle, number of cycles, and infusion times failed to reach significance using multivariate analysis.

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