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Incidence and trends of limb amputation in first nations and general population in Saskatchewan, 2006-2019.

PLoS One · 2021 · PMC8274839 · PMID 34252158

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an increasing trendno p-value reported
The RI age-adjusted rate showed an increasing trend in rate between 2006 and 2007 and a declining trend after 2007.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.