Working memory, cortical dopamine tone, and frontoparietal brain recruitment in post-traumatic stress disorder: a randomized controlled trial.

At one standard deviation below average PTSD severity, performance approached significant worsening on tolcapone versus placebo (t(32.1) = −1.956, p = 0.0592, d = 0.6905), while at two standard deviations above average PTSD severity, performance approached significant improvement on tolcapone versus placebo (t(32.1) = 2.002, p = 0.0538, d = 0.7067).

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