Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2.

The correlation analysis based on R 2 score revealed that Pim1 protein expression significantly and positively correlated with HER2 and HER3, but not HER4, protein expressions and that the correlation between Pim1 and EGFR expressions approaches marginal significance ( Figure 1B ).

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