Precision Medicine and Heterogeneity of Treatment Effect in Therapies for ARDS.

57 , 58 However, application of longer durations of prone positioning led to a nonsignificant trend toward mortality in patients with a Pa o 2 /F io 2 ratio < 100 mm Hg and 132 ± 74 mm Hg. 59 , 60 Based on these findings, the Effect of Prone Positioning on Mortality in Patients with Severe Acute Respiratory Distress Syndrome (PROSEVA) trial included prognostic enrichment to select patients with a

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There was no benefit, and a possible trend toward harm, in patients who did not require any oxygen (17.8% vs 14.0%; rate ratio, 1.19; 95% CI, 0.91-1.55).

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