Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.

112 An earlier review combining trials in primary and secondary prevention showed a similarly small absolute increased risk of myalgia, which was borderline significant. 113 For clinically confirmed muscle disorders, previous reviews that included secondary prevention trials detected associations between statins and myopathy and rhabdomyolysis based on larger numbers of participants. 114 115 The analyses were still underpowered, however, given the low incidences of muscle disorders in the statin and control groups, similar to the data in our review.

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