Dnmt1 has de novo activity targeted to transposable elements.

Nat Struct Mol Biol · 2021 · PMC8279952 · PMID 34140676

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highly significantP < 2.2 × 10 −16actually significant

IAPs are specific targets of Dnmt1’s de novo activity Next, we compared the DMR distribution over genomic features and found a highly significant enrichment at LTRs, which is independent of regional CpG density ( P < 2.2 × 10 −16 , Wilcoxon test, DMRs compared with CRs; Fig. 2e and Extended Data Fig. 2b ).

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