Robust Angiogenesis and Arteriogenesis in the Skin of Diabetic Mice by Transient Delivery of Engineered VEGF and PDGF-BB Proteins in Fibrin Hydrogels.

Front Bioeng Biotechnol · 2021 · PMC8281302 · PMID 34277588

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borderline significantno p-value reported

Therefore, both the total vessel length ( Figure 5d : V = 2.5 ± 0.7 mm, VP = 5.7 ± 2.0 mm, p = 0.05, n = 9 per group) and the total angiogenic volume ( Figure 5e : V = 0.06 ± 0.02 mm 3 , VP = 0.12 ± 0.03 mm 3 , p = 0.17, n = 9 per group) in the implantation sites of TG-VEGF + TG-PDGF-BB fibrin gels were about 2-fold greater than those with TG-VEGF alone, though these differences were borderline significant.

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