Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X<sub>2</sub> and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23.

Sci Rep · 2021 · PMC8282855 · PMID 34267232

Europe PMC DOI

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closest p · 1.0× alpha

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highly significantP < 0.05actually significant

Optimization of antibiotic production by response surface methodology (RSM) The results showed that the linear and quadratic effects of pH, temperature, inoculum volume, and agar concentrations were highly significant (P < 0.05), but the interactive effects of agar concentrations and inoculum volumes were insignificant (P > 0.05).

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