Using AMANHI-ACT cohorts for external validation of Iowa new-born metabolic profiles based models for postnatal gestational age estimation.

To evaluate the discriminatory ability of the estimated GA in identifying pre term births, ROC analysis performed indicated a highly significant ability, with area under curve of 0.86 (conservative bootstrap 95% CI = 0.83 to 0.89); P < 0.001) and a Youden Index of 0.58 (95% CI = 0.51 to 0.64) with a corresponding sensitivity of 80.7% and specificity of 77.6% ( Figure 2 , Panels A and B).

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