Comparison of Changes in PPV Using a Tidal Volume Challenge with a Passive Leg Raising Test to Predict Fluid Responsiveness in Patients Ventilated Using Low Tidal Volume.

During PLR test, there was a significant decrease in PPV (delta PPV2) in responders with 87.5% sensitivity and 80% specificity (best cutoff value 2.5 and area under the curve of 0.877); the mean CO increased significantly with PLR test in responders 0.18 ± 0.10 compared to − 0.01 ± 0.1 in nonresponders; this was highly significant with statistically best cutoff value of 6.5% with 0.94 area under the curve, 93.8% sensitivity, and 86.7% specificity, but sensitivity was 75% with specificity of 86% with cutoff value of 10% (0.099) increase in CO ( Table 4 ).

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