An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome.

24 Similarly, a positive trend was observed between methylation and gene expression in exon boundaries (±150 bp), especially in cancer and matched adjacent paracancer tissues.

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A decreasing trend of global 5mC and 5hmC levels from healthy groups to CCs We performed WGBS‐seq and oxWGBS‐seq on 16 genomic DNA extracted from two health cervical (healthy) tissues, six CIN tissues (CIN1, CIN2, CIN3, n = 2 for each stage), and four paired CC tissues, and adjacent paracancer tissues (Figures S1 and S2 ).

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