The CD44 receptor on the surface of mastocytes is a receptor for HA and such an interaction may be significant in their migration. 32 , 55 Treatment involves the immediate administration of antihistamine drugs, systemic GCS, or adrenaline. 46 Early Reactions The first reports were published by Turkmani et al and described women aged 22–65 who had undergone procedures with HA manufactured by various companies. 39 Lesions presented as erythema and painful edema of the face at the sites of injected fillers.
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