Risk Potential for Organ Dysfunction Associated With Sodium Bicarbonate Therapy in Critically Ill Patients With Hemodynamic Worsening.

The adjusted OR for risk potential of newly d/eOD subsequent to SBT was increased with a borderline significance in a subgroup of patients who had AG ≥ 15 [adjusted OR (95% CI): 1.52 (0.97, 2.37), p = 0.067] and AKI stage ≥2 [adjusted OR (95% CI): 1.51 (0.99, 2.33), p = 0.058, Figure 3 ].

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In addition, this side effect was borderline significant in subgroups of patients with either AG values remaining ≥15 or severe AKI (fulfilling the KDIGO criteria for stage 2 and stage 3, Figure 3 ), who might benefit from further hemodynamic optimization in the acute phase of critical illness ( 31 ).

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