HLA class-I-peptide stability mediates CD8<sup>+</sup> T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.

Comparison of relative T m of soluble HLA monomers with normalized anti-HLA MFI values generated by the cell-based assay revealed a striking and highly significant correlation at peptide concentrations of 100 μM (R = 0.87, p = 0.0002) and 10 μM (R = 0.85, p = 0.0004) ( Figures 3 D and 3E).

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