highly significantp -value < 0.0001
GradCAM which demonstrated that the sensitivity ( p -value < 0.0001 and p -value < 0.0001 respectively) was significantly different however specificity between HR-CAM and Zhou’s CAM did not vary ( p -value > 0.05) conversely between HR-CAM and GradCAM it was highly significant ( p -value < 0.0001).