Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.

Consistent with previous publications [ 60 ], common variant PRS for both BD and schizophrenia were highly significant in the combined meta-analysis (p BD = 1.52 × 10 −41 and p SZ = 1.51 × 10 −32 , Table S8 ), but explained only a small proportions of variance in disease risk (~1–4%) in individual BSC studies, again demonstrating the shared genetic etiology of these psychiatric conditions, at least from common variants and in contrast to rare variant analyses.

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