The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene.

Skelet Muscle · 2021 · PMC8296708 · PMID 34294164

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highly significantno p-value reported

The antifibrotic effect was evident at the top doses and this contrasts with the dose dependence of functional improvements that were highly significant also at lower doses.

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