DGKζ exerts greater control than DGKα over CD8⁺ T cell activity and tumor inhibition.

Using principal component analyses (PCA), RNA-seq results indicated that stimulated naïve DGKζ −/- CD8 + T cells had more extensive changes than DGKα −/- cells, relative to wildtype T cells ( Figure 2a ), a finding supported by assessment of highly significant changes in gene expression (fold change greater than 2 and p -value cutoff of 1x10 5 , Figure 2b ) and in volcano plots assessing log-2 fold changes as a function of log-10-adjusted p -values ( Figure 2c, 2d ).

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