TIRAP in the Mechanism of Inflammation.

Front Immunol · 2021 · PMC8297548 · PMID 34305934

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highly significantno p-value reported

This interaction is highly significant in TLR2 and TLR6 heterodimer signaling, resulting in the activation of PI3K-dependent phosphorylation of Akt, PIP 3 [phosphatidylinositol (3,4,5)P 3 ] generation, and polar shape changes of the macrophage ( 16 ).

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