As the field of risk assessment progresses, there has been an increasing trend to simplify the variables and scoring calculations.
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In a study of 1,198 patients, a single-nucleotide polymorphism (rs11157866) in the G-protein alpha and gamma subunits gene was significantly associated with a combined improvement in functional class and 6MWD at 12 and 18 months and marginally significant at 24 months. 55 The largest GWAS to date included 11,744 individuals, of whom 2,085 were diagnosed with PAH.