GSEA analysis revealed a highly significant correlation of EF DBD-activated and repressed genes when compared to EF DBD+-regulated genes (NES= 1.78 and −2.90, respectively; Supplementary Figure 4D - E ).
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The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.
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