Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.

Transl Psychiatry · 2021 · PMC8302633 · PMID 34301914

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highly significantno p-value reported

Notable exceptions to these opposite trends in association between APOE-ε4 and APOE-ε2 and the lipid traits are observed for triglycerides, in which there is a highly significant positive association with APOE-ε4 and APOE-ε2, and decreased levels of lipoprotein A with APOE-ε4 and APOE-ε2 dosage.

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of borderline significanceno p-value reported

There were also negative correlations of borderline significance between APOE-ε4 and APOE-ε2 for blood biochemistry, and between APOE-ε4 and familial risk for metabolic health traits.

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