Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition.

LY3009120 increased the percentage of early apoptotic cells to 15%, and LY3009120 plus hydroxyurea induced a highly significant induction of 35% early apoptosis after 24 h ( Figure 2 b).

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