A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants.

J Pers Med · 2021 · PMC8307171 · PMID 34357110

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highly significantno p-value reported

Both parametric (Pearson correlation coefficient) and non-parametric (Spearman’s rank correlation coefficient) correlation analysis indicated a highly significant correlation between the forskolin-activated basal I sc and the VX-809 or VX-661 corrected I sc ( Figure 4 C), similar to the correlation between the VX-809 corrected and basal CFTR activity observed in a panel of rare CFTR genotypes in HNE [ 48 ].

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