BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia.

1 In Kelantan, the incidence of CRC shows an increasing trend from 1987 to 2007. 2 CRC commonly occurs in the older age group with a mean age of 61.6 years. 3 Globally, approximately 5% of CRC were young-onset. 4 The incidence of CRC in this young population was reported to range from 0.4% to 35.6% relative to the total number of patients with CRC. 5 In Malaysia, the incidence increased from 5% to 7% from 2008 to 2013. 3 The microsatellite instability (MSI) pathway contributes to 15% of sporadic young CRC and more than 95% of hereditary nonpolyposis CRC (HNPCC) or Lynch syndrome.

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