In contrast, there was no change in body mass in SI group animals when compared with the baseline value ( figure 2B , left panel; p=0.826) and in fact showed a reduction in mass of approximately 25 g when compared with the SHAM animals ( figure 2B , left panel; p=0.2863) and a marginally significant delta value ( figure 2B , right panel; p=0.05).
A recent review of clinical trial studies regarding ARDS in adults included 177 articles with 25 966 subjects and found a decreasing trend in mortality in prospectively designed studies over time. 2 However, a significant decline in overall mortality has yet to be seen despite the wide adoption of low-volume lung protective ventilation made popular by the ARDSNet trial. 2 The current mortality rate of ARDS remains high, ranging from 3