Multiscale neural modeling of resting-state fMRI reveals executive-limbic malfunction as a core mechanism in major depressive disorder.

5 C, D indicated that the correlation between estimated and ground-truth EC was highly significant ( p < 1e-5) for low NSR (NSR < 0.3) and remained significant ( p < 0.005) even for large NSR (NSR ≥ 0.3).

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The marginal difference in EC is not likely due to the excessive removal of weak connections because only two inter-regional connections display marginal significance in the network without removal of weak connections (Supplemental Fig.

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