Trends in antibiotic resistance for over 700,000 Escherichia coli positive urinary tract infections over six years (2014-2019) from a university teaching hospital.

Amoxicillin, pivmecillinam, and trimethoprim also showed a decrease in antibiotic resistance over the six years (a decreasing trend of 2.74% (p <0.001), 6.25% (p <0.001) and 2.54% (p <0.001) per year respectively).

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Conclusions Despite our protocol based antibiotic policy, although the overall antibiotic resistance remained stable, there was an increasing trend in antibiotic resistance for more commonly used antibiotics including ciprofloxacin, co-amoxiclav, gentamicin, and tazocin reflecting their overall use for prophylaxis and treatment.

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