JFK Is a Hypoxia-Inducible Gene That Functions to Promote Breast Carcinogenesis.

Obesity has been proposed to be a highly significant risk factor for breast carcinogenesis and aggressiveness ( Perez-Hernandez et al., 2014 ), as excessive adipose tissue in obese patients not only alters the local microenvironment by remodeling the extracellular matrix but also provides both energy and niches for cancer cell proliferation and invasion ( Seo et al., 2015 ; Gao et al., 2020 ).

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