Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.

Repeated exposure to my blu aerosol, at all doses tested, did not significantly induce the 3D lung model to elevate MMP (-1, 3 & 9) secretion, although at 90-puffs, MMP-3 secretion appeared to have an increasing trend, however, this was not statically significant. 4.3.4 IL-1β IL-1β levels increased significantly throughout the study after exposure to 90 puffs 3R4F, and to a lesser extent after 60-puffs.

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