Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals.

When including precuneal Aβ slope and the interaction term (Aβ precuneus *∆Aβ precuneus ) in the model, the predictive power of baseline amyloid burden in this ROI became highly significant (β = −0.29, t = −3.7, P < .001), and both precuneus slope (β = −9.71, t = −2.2, P = .030) and the interaction term (β = 8.71, t = 2.6, P = .011) were marginally predictive of changes in MMSE.

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At the cluster level, only amyloid burden and accumulation in the cluster 2 ROI could significantly predict changes in MMSE over time, with baseline amyloid being a significant predictor (β = −0.37, t = −3.0 P = .003), and its interaction with slope a marginally significant predictor (β = 14.16, t = 2.1, P = .038).

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