Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia.

By contrast, the discovery cohort had a median of four (p10-p90: 1-6) and five (p10-p90: 2-9) mutations at the first and second samplings, respectively, representing a highly significant increase in the number of mutations during disease progression ( P <0.0001).

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Remarkably, the control and discovery cohorts had a similar number of mutations at the time of diagnosis ( P =0.097), although a slight trend was observed, while patients who progressed showed a significantly higher number of mutations at the time of sAML than the control patients at the second sampling ( P =0.027) ( Figure 1A ).

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