microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.

J Tissue Eng · 2021 · PMC8330460 · PMID 34377430

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Furthermore, the results of Western blot analysis demonstrated an increasing trend in the protein expression levels of collagen II and aggrecan, yet a decreasing trend in those of MMP13 and MMP3 following miR-129-5p mimic, which could be countered following miR-129-5p inhibition ( Supplemental Figure S2B ).

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