Comparison of cell therapy and other novel adjunctive therapies combined with core decompression for the treatment of osteonecrosis of the femoral head : a systematic review and meta-analysis of 20 studies.

The overall estimate of effect size for WOMAC favoured the cell therapy group, although it reached only borderline significance levels in the presence of a huge degree of statistical heterogeneity (I 2 = 85%, p = 0.009, chi-squared test) (MD = −7.15, 95% CI = -14.52 to 0.02, Z = 1.90, p = 0.06, chi-squared test) (Supplementary Figure c).

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