highly significantp<0.001
Data from nearly 100,000 patients indicated that non-PRX AF is associated with a highly significant increase in thromboembolism with multivariable adjusted HR 1.38 (95% CI [1.19–1.61]); p<0.001, compared with PRX AF, while again rates of bleeding were similar, with adjusted HR 1.025 (95% CI [0.89–1.17]); p=0.715.[ 49 ] This meta-analysis suggests that patients with PRX AF have a lower risk of stroke than those with non-PRX AF, but it remains unclear if AF pattern is an independent predictor of stroke or rather a reflection of a different patient profile in terms of risk factors and comorbidities.