Transient genomic instability drives tumorigenesis through accelerated clonal evolution.

Genes Dev · 2021 · PMC8336898 · PMID 34266887

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highly significantno p-value reported

6 C) and was highly significant in tumor types with known involvement of c-MYC dysregulation such as diffuse large B-cell lymphoma (DLBC), uterine corpus endometrial carcinoma (UCEC), prostate adenocarcinoma (PRAD), and lung adenocarcinoma (LUAD) ( Koh et al. 2010 ; Iwakawa et al. 2011 ; The Cancer Genome Atlas Research 2013 ; Nguyen et al. 2017 ).

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