A breakthrough-like effect of metformin reduces peripheral resistance to triiodothyronine in euthyroid, non-insulin-resistant, type 2 diabetic patients.

Endocr Connect · 2021 · PMC8346195 · PMID 34137729

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highly significantno p-value reported

Results Metformin reduces T3, T3/T4 ratio, fructosamine, and HOMA-IR After 4 weeks of metformin therapy, a highly significant decrease was found in the level of T3 ( Fig. 1 panel A ).

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