Barely Significant
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Risk of Heart Disease after Cholecystectomy: A Nationwide Population-Based Cohort Study in South Korea.

J Clin Med · 2021 · PMC8348353 · PMID 34362037

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considerably significantno p-value reported
At the same time, the socioeconomic burden of heart disease is now considerably significant and rising steadily and efforts have been to modify and identify risk factors for prevention of heart disease globally [ 11 , 12 , 13 , 14 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.