Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues.

The brain showed an increasing trend in gene expression with age ( Tan module; bicor=0.86; p-value =3e-13), with the shift from down- to up-regulation occurring around the transition from middle- to old-age (15 to 18 months) ( Figure 3A , upper left panel).

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High correlations between these two measures are indicative of genes that are highly significant for the aging process and for sex differences in gene expression, being as well highly important to the module.

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The Blue module (bicor=-0.57; p-value =5e-04) exhibits a decreasing trend in gene expression with age, and the transition from up- to down-regulation happened at old-age (18 to 21 months) ( Figure 3A , upper left panel).

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