Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties.

Enhanced perfusion associated with increased capillary density in iEC-treated mice In comparison to the control group, mice treated with neonatal-derived iECs demonstrated a positive trend to increased capillary density, though this was non-significant (control vs. neonatal-derived iECs; 1.31 ± 0.20 vs. 1.45 ± 0.32, p> 0.05), and mice treated with patient-derived iECs from patients 1 and 2 demonstrated significantly increased capillary density (control vs. patient 1 vs. patient 2; 1.31 ± 0.20 vs. 1.64 ± 0.25, p< 0.05 vs. 1.60 ± 0.15, p< 0.05) ( Fig 5 ).

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