Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice.

Further, the effects of ethanol leading to the reduction in acetyl-CoA pathway is a highly significant and relevant component of the loss of butyrate production and functional dysbiosis of the microbiome because i) acetyl-CoA pathway predominates butyrate production as compared to lysine, glutarate, and 4-aminobutyrate pathway and ii) reduction in acetyl-CoA pathway cannot be sufficiently compensate

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