Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium.

J Psychopharmacol · 2021 · PMC8358538 · PMID 34238049

Europe PMC DOI

hedged sentence

0.0001

closest p · 0.0× alpha

0.0001

boldest claim

The sentences

highly significantp < 0.0001actually significant

Meta-analyses Random-effects meta-analysis of trials of adding SGAs versus placebo to antidepressants yielded highly significant superiority of SGAs overall (OR = 1.59 [CI: 1.44–1.75]; z = 9.16, p < 0.0001; Figure 1(a) ).

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.