Outpatient antibiotic use in British Columbia, Canada: reviewing major trends since 2000.

JAC Antimicrob Resist · 2021 · PMC8360297 · PMID 34396123

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a decreasing trendno p-value reported

For penicillins (J01C), a decreasing trend was led by amoxicillin, which accounts for most prescriptions issued (range 169 to 126 prescriptions per 1000 population) and decreased in use by 25%.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.