Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1<sup>+/-</sup>/Tis21<sup>KO</sup> Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611.

Front Oncol · 2021 · PMC8362831 · PMID 34395258

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highly significantno p-value reported

Nevertheless, the analysis of the phosphorylation level of mTOR substrates, such as S6 at Ser235/236 and 4EBP1 at Thr37/46, revealed that the mean percentage of phosphorylated S6 protein versus total S6 protein presented a highly significant increase in Ptch1 +/− /Tis21 KO tumors ( Ptch1 +/− /Tis21 KO vs.

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