Deuterium-Stabilized (<i>R</i>)-Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity.

Similarly, serum adiponectin—a known marker of PPARγ activation—was significantly increased with pioglitazone and d‐S‐pio, while only a nonsignificant trend was seen with PXL065 (Fig. 4 B), likely because of exposure to the PPARγ‐active ( S )‐enantiomer.

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