Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Several paralog and collateral synthetic lethal interactions were highly significant in our analysis, including those previously reported for MAGOH-CDKN1B and PRMT5 / WDR77 with CDKN2A ( Figures 1B and 1D ; Kryukov et al., 2016 ; Viswanathan et al., 2018 ) as well as multiple new interactions, including ones linked to the loss of KEAP1 , STK11 , ATM , TP53 , CDH1 , and SMAD4 ( Figures 1B , 1D , and S1G ; Table S1 ).

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